Arun R Shrivats

About

I bring a decade of healthcare product experience built on a foundation in genome editing bench research. At Exact Sciences, I've combined product, strategy, operations, and partnerships in the pursuit of eradicating cancer.

Today, I lead a $700M global early-stage cancer diagnostics business. My portfolio spans Oncotype DX, Riskguard hereditary cancer testing, AI-powered digital pathology products, and a multi-product portfolio platform serving oncologists, surgeons, pathologists, and genetic counselors. I lead cross-functional initiatives across R&D, clinical, medical, operations, marketing, training, and sales to bring cancer diagnostics to market at scale. Previously, I led Exact's Corporate Strategy team focused on the Oncology and International businesses.

Prior to Exact, I spent ~5 years as a strategic partner to pharma, biotech, diagnostics, and tools organizations, first at L.E.K. Consulting (leaving as Engagement Manager) and later at Prescient Advisory, where I helped build an advisory team within the Prescient Healthcare Group.

Before consulting, I worked at Harvard University's Wyss Institute (Disease Biophysics Group), where I helped develop microphysiological chip-based platforms to model functional and diseased organ states and support drug development for complex diseases. I had the opportunity to patent this technology and navigate an out-licensing agreement through an appointment with Harvard's Office of Technology Development. Earlier experiences include LifeNet Health, Carnegie Mellon University, and the University of Toronto.

Outside of work, I play golf and tennis, bike around San Francisco, and enjoy family trips to state and national parks.

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Portfolio

• Insights · 2017

  Kfoury, J., Shrivats, A.R., Robertson, S., Grabenstatter, K. (2017) The New Normal for Biopharma as Price Growth Finally Slows. L.E.K. Insights.
• Journal · 2015

  Shrivats, A.R., McDermott, M.C., Klimak, M., Averick, S., Pan, H., Matyjaszewski, M., Mishina, Y., Hollinger, J.O. (2015) Nanogel-mediated RNAi Against Runx2 and Osx Inhibits Osteogenic Differentiation in Constitutively Active BMPR1A Osteoblasts. ACS Biomaterials Science and Engineering.
• Journal · 2015

  Shrivats, A.R., Mishina, Y., Averick, S., Matyjaszewski, M., Hollinger, J.O. (2015) In Vivo GFP Knockdown by Cationic Nanogel-siRNA Polyplexes. Bioengineering 2 (3), 160-175.
• Journal · 2015

  Shrivats, A.R., Mackenzie, M.C., Konkolewicz, D., Averick, S.E., McDermott, M.C., Hollinger, J.O., Matyjaszewski, K. (2015) Synthesis of Poly(meth)acrylates with Thioether and Tertiary Sulfonium Groups by ARGET ATRP and their use as siRNA Delivery Agents. Biomacromolecules 16 (1), 236-245.
• Conference · 2014

  Shrivats, A.R. (2014). Inhibition of Osteogenic Differentiation by Nanogel-Mediated siRNA Delivery. FOP Drug Development Forum (Boston, Massachusetts). November 20th, 2014. Podium.

• Journal · 2014

  Shrivats, A.R., Hsu, E., Averick, S., Klimak, M., Watt, A.C.S., DeMaio, M., Matyjaszewski, K., Hollinger, J.O. (2014) Cationic Nanogel-mediated Runx2 and Osterix siRNA Delivery Decreases Mineralization in MC3T3 Cells. Clinical Orthopaedics and Related Research.
• Review · 2014

  Shrivats, A.R., McDermott M.C., Hollinger, J.O. (2014) Bone Tissue Engineering: State of the Union. Drug Discovery Today 19 (6), 781-786.
• Review · 2014

  Shrivats, A.R., and Hollinger, J.O. (2014). The Delivery and Evaluation of RNAi Therapeutics for Heterotopic Ossification Pathologies. In Biomimetics and Stem Cells, Methods in Molecular Biology 1202, 149-160.
• Conference · 2014

  Shrivats, A.R., McDermott, M.C., Averick, S., Cho, H., McKenzie, M., Matyjaszewski, K., Mishina, Y., et al. (2014). RNA Interference Therapeutics For Fibrodysplasia Ossificans Progressiva. In Orthopaedic Research Society (New Orleans, Louisiana). March 18th, 2014. Podium.

• Journal · 2014

  Hsu, E.W., Liu, S., Shrivats, A.R., Watt, A.C.S., McBride,..., Matyjaszewski, K., and Hollinger, J.O. (2014). Cationic Nanostructured Polymers for siRNA Delivery in Murine Calvarial Pre-Osteoblasts. Journal of Biomedical Nanotechnology 10 (6), 1130-1136.
• Conference · 2013

  Shrivats, A.R., Liu, S., Watt, A., Hsu, E., Averick, S., Cho, H., Alvarez, P., McBride, S., Mishina, Y., et al. (2013). The Next Generation of Cationic Polymers for Gene Delivery. In Material Science and Technology (Montreal, Quebec). October 30th, 2013. Podium.

• Book Chapter · 2013

  Hsu, E., Alvarez, P, Schutte, L, Donovan, A., Liu, S., Shrivats, A.R., Hollinger, J.O. (2013). Animal Models and Clinical Applications: Bone Regeneration. Biomaterials and Regenerative Medicine. Cambridge University Press. In press.

• Conference · 2013

  Shrivats, A.R., Hsu, E., Watt, A., McBride, S., Liu, S., Alvarez-Urena, P., Averick, S., Cho, H., Paredes, E., et al. (2013). The development of safe and effective polymeric carriers for siRNA delivery. In Society for Biomaterials (Boston, Massachusetts). April 13th, 2013. Podium.

• Journal · 2012

  Averick, S.E., Paredes, E., Irastorza, A., Shrivats, A.R., Srinivasan, A., Siegwart, D.J., Magenau, A.J., Cho, H.Y., Hsu, E., Averick, A.A., et al. (2012). Preparation of cationic nanogels for nucleic acid delivery. Biomacromolecules 13, 3445-3449.
• Book Chapter · 2012

  Shrivats, A.R., Alvarez-Urena, P., Schutte, L., and Hollinger, J.O. (2012). Bone Regeneration. In Principles of Tissue Engineering, R. Lanza, R. Langer, and J.P. Vacanti, eds. In press.

• Book Chapter · 2011

  Rauh, F., Dornish, M., Street, R., and Shrivats, A.R. (2011). Complex Polysaccharides: Chitosan and Alginate. In An Introduction to Biomaterials, Second Edition, J.O. Hollinger, ed. (CRC Press). In press.

• Journal · 2011

  Cho, H.Y., Srinivasan, A., Hong, J., Hsu, E., Liu, S., Shrivats, A., Kwak, D., Bohaty, A.K., Paik, H.J., Hollinger, J.O., et al. (2011). Synthesis of biocompatible PEG-Based star polymers with cationic and degradable core for siRNA delivery. Biomacromolecules 12, 3478-3486.
• Conference · 2010

  Srinivasan, A., Sriram, S., Watt, A., Hsu, E., Shrivats, A., Cho, H., Matyjaszewski, K., and Hollinger, J. (2010). Delivery of siRNA Using Cationic Nanostructured Star Polymers to Prevent Myoblast Cell Differentiation to Bone. In Tissue Engineering and Regenerative Medicine International Society (Orlando, Florida). Podium.